Codon usage: mutational bias, translational selection, or both?

نویسندگان

  • P M Sharp
  • M Stenico
  • J F Peden
  • A T Lloyd
چکیده

7. Karimpour, I., Cutler, M., Shih, D., Smith, J. and Kleene, K. (1992) DNA Cell Hiol. 11,693-699 8. Hill, K. E., Lloyd, R. S., Yang, J. G., Read, R. and Hurk, R. F. (1991) J. Biol. Chem. 266,10050-10053 9. Burk, R. F., Lawrence, R. A. and Lane, J. M. (1980) J. Clin. Invest. 65, 1024-1031 10. Rurk, R. F., Hill, K. E., Read, R. and Rellew, T. (1991) Am. J. Physiol. 261, E26-E30 11. Yang, J. G., Morrison-Plummer, J. and Burk, R. F. (1987) J. Biol. Chem. 262,13372-1 3375 12. Read, R., Bellew, T., Yang, J. G., Hill, K. E., Palmer, I. S. and Burk, R. F. (1990) J. Biol. Chem. 265, 1789917905 13. Hill, K. E., Lloyd, R. S. and Burk, R. F. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 537-541 14. Berry, M. J., Banu, L., Chen, Y., Mandel, S. J., Kieffer, J. D., Harney, J. W. and Larsen, P. R. (1 99 1 ) Nature (London) 353,273-276 835

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Codon usage bias has been documented in a wide diversity of species, but the relative contributions of mutational bias and various forms of natural selection remain unclear. Here, we describe for the first time genome-wide patterns of codon bias at 4623 genes in the purple sea urchin, Strongylocentrotus purpuratus. Preferred codons were identified at 18 amino acids that exclusively used G or C ...

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Codon usage bias (CUB) results from the complex interplay between translational selection and mutational biases. Current methods for CUB analysis apply heuristics to integrate both components, limiting the depth and scope of CUB analysis as a technique to probe into the evolution and optimization of protein-coding genes. Here we introduce a self-consistent CUB index (scnRCA) that incorporates i...

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 21 4  شماره 

صفحات  -

تاریخ انتشار 1993